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Published Date: 2017-04-22 10:13:46
Subject: PRO/AH/EDR> Avian influenza, human (45): China, H7N9
Archive Number: 20170422.4982785
AVIAN INFLUENZA, HUMAN (45): CHINA, H7N9
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A ProMED-mail post
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ProMED-mail is a program of the
International Society for Infectious Diseases
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In this Update:
[1] Beijing H7N9 Case numbers 2017
[2] Beijing(17-19 Apr 2017)
[3] Sichuan
[4] Liaoning
[5] Increased Pathogenicity

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[1] Beijing H7N9 Case numbers 2017
Date: Wed 19 Apr 2017 00:01 UTC+8
Source: Shanghai Daily [edited]
http://www.shanghaidaily.com/nation/Bird-flu-in-Beijing/shdaily.shtml


Beijing has reported 10 human H7N9 avian flu cases so far this year [2017], the capital's Center for Disease Prevention and Control said yesterday [Tue 18 Apr 2017]. The latest cases were reported on April 5 [2017]. Both patients are said to have had contact with live poultry. One patient died from the infection on April 8 [2017] while the other is still being treated in hospital and is said to be in a stable condition.

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[2] Beijing (17-19 Apr 2017)
Date: Thu 20 Apr 2017 14:32 PM
Source: FIC (Flu Information Centre/Flu in China) [edited]
http://www.flu.org.cn/en/news_detail?action=ql&uid=MjI0OA&pd=YXRsbXBw&newsId=19291


According to the report on Beijing CDC website, 3 additional human H7N9 AIV cases have been confirmed from 17 to 19 April [2017]. Those 3 were all local cases. Beijing has reported 7 local cases and 6 imported cases since the beginning of 2017.During the epidemiological investigation of those 7 local cases, all had previous live poultry contact or live poultry market exposure history (3 had dead/sick poultry contact history), 5 cases had purchased live poultry from vendors.

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[3] Sichuan
Date: Wed 19 Apr 2017 17:46 PM
Source: FIC (Flu Information Centre/Flu in China) [edited]
http://www.flu.org.cn/en/news_detail?action=ql&uid=MjI0OA&pd=YXRsbXBw&newsId=19285


A total of 2 human H7N9 AIV cases have been reported in Sichuan province on [Wed 19 Apr 2017] after the confirmation from Sichuan provincial CDC.

1) The 60-year-old male patient, surname [W], decoration worker, lived in Tianpeng town of Pengzhou city of Chengdu city, was in critical condition and remained in hospital for treatment. No close contacts showed ILI symptoms so far.

2) The 55-year-old male patient, surname [T], construction worker, lived in Logistic harbor of Chuanshan district of Suining city, was in serious condition and remained in hospital for treatment. No close contacts showed ILI symptoms so far.

According to the weekly AIV report from Hong Kong CHP, another human H7N9 AIV case reported in Suining city on [Fri 14 Apr 2017] (The 51-year-old male patient, has severe pneumonia).

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[4] Liaoning
Date: Wed 20 Apr 2017
Source: FIC (Flu Information Centre/Flu in China) [edited]
http://www.flu.org.cn/en/news_detail?action=ql&uid=MjI0OA&pd=YXRsbXBw&newsId=19298


According to the HFPC of Liaoning province, one human H7N9 case was confirmed on [Thu 20 Apr 2017] after the reconfirmation of positive test result from provincial CDC. The 61-year-old female patient, surname [Z], lived in Hongbaoshan village of Shilihe street of Sujiatun district of Shenyang city, had sick/dead poultry contact history, onset of symptoms on [Tue 4 Apr 2017], remained in designated hospital for treatment and quarantine, and was in critical condition.

Liaoning province has reported 4 human H7N9 AIV cases since 2017, includes one case confirmed by Beijing in February [2017].

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[5] Increased Pathogenicity
Date: Thu 13 Apr 2017
Source: SciNet Dev [edited]
http://www.scidev.net/global/disease/news/virulent-bird-flu-strain-china.html


A new strain of avian influenza that has high pathogenicity in poultry, and which can be deadly for humans, has resurfaced in China with pandemic potential -- prompting calls for a quick and thorough response to halt its advance and contain the changing H7N9 virus.

Until recently, H7N9 has shown low pathogenicity, meaning that it may cause mild or no illness in poultry. Evidence from China's Guangdong province suggests that the new strain has shifted to high pathogenicity in poultry while retaining its capacity to cause severe problems in humans. This is said to be a genetic change that could lead to high mortality for birds within 48 hours of infection and cause high economic losses for those engaged in poultry production and sales. "China has embarked on intensified surveillance and results are awaited to better assess the epidemiology and potential spread of this new, highly pathogenic virus."

Meanwhile, human cases of the H7N9 virus, 1st detected in China 4 years ago have been increasing since December 2016. An update in March reported 20 human cases in 8 Chinese provinces: Hunan, Jiangsu, Guangxi, Fujian, Guizhou, Chongqing, Shandong and Zhejiang, according to the Food and Agriculture Organization (FAO). In the latest update [Wed 12 Apr 2017], the FAO reported additional 16 human cases and 2 detected in birds. As before, most patients mentioned visiting live bird markets or coming into contact with infected birds. There is, however, no indication that the news strain has spread to wild birds.
"China has embarked on intensified surveillance and results are awaited to better assess the epidemiology and potential spread of this new, highly pathogenic virus," Sophie Von Dobschuetz, animal health officer at FAO, tells SciDev.Net. "FAO, through its office in Beijing, is in regular dialogue with the ministry of agriculture and providing recommendations for surveillance and control."

The H7N9 strain currently circulating in China has not been noted in poultry populations in other countries, Matthew Stone, deputy director general of the World Organization for Animal Health, tells SciDev.Net.

"However, these countries (with poultry farms) remain at risk and need to be vigilant for a potential incursion of the virus, in a low or highly pathogenic form," Stone adds. "Constant surveillance of domestic poultry as well as wild birds by national veterinary services is essential to reduce the risks associated with virus spread and protect both animal and human health, as well as livelihoods."
According to Stone, live bird markets remain the main source of virus spread among poultry and from poultry to humans and South-East Asian countries need to implement targeted and widespread monitoring to detect and respond to the virus.

Prevention measures should include laboratory testing, increased hygiene at live-bird markets and on-farm biosecurity to reduce exposure, he says.

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[The increased pathogenicity of Influenza A/H7N9 in poultry is a new and alarming change with serious economic implications. However, this also indicates options for quick detection of disease in poultry as compared to the earlier 3-4 years, when the effected poultry was largely asymptomatic or showed mild disease. The majority of human cases reported contact with birds and also visits to wet markets, and perhaps the absence of severe disease in the birds facilitated transmission to humans.

Furthermore, the number of reported human cases has been much higher in 2017 than previous years, which highlights the need for enhanced surveillance as well as better diagnostic preparedness, so that prompt control and containment measures can be instituted. - Mod.UBA


A HealthMap/ProMED-mail map can be accessed at: http://healthmap.org/promed/p/155.]

See Also

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Avian influenza, human (23): China, Taiwan, H7N9, WHO, genetic mutations 20170223.4858369
Avian influenza, human (22): China (GX, SD), H7N9, WHO updates, vaccine 20170222.4852285
Avian influenza, human (21): China (GZ) H7N9 20170219.4849594
Avian influenza, human (20): China (SC, YN, BJ), H7N9, death toll 20170215.4841682
Avian influenza, human (10): Indonesia (LA) RFI 20170123.4785841
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2016
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Avian influenza, human (72): China (HK) H7N9, fatal 20161229.4727495
Avian influenza, human (68): China, H7N9 20161218.4705001
Avian influenza, human (67): WHO, H5N6, H7N9, risk assessment 20161212.4689184
Avian influenza, human (66): China (GD) H7N9 20161210.4689085
Avian influenza, human (65): China (HN) H5N6 20161123.4646005
Avian influenza, human (64): China (ZJ,JS) H7N9 20161114.4624064
Avian influenza, human (60): China (JX) H9N2 20160912.4481431
Avian influenza, human (58): China, H7N9, update, WHO 20160820.4422893
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Avian influenza, human (55): China (mainland) H7N9, fatal 20160722.4362599
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Avian influenza, human (53): China (LN) H7N9, fatal 20160710.4332434
Avian influenza, human (52): WHO, human-animal interface 20160625.4308644
Avian influenza, human (48): China (HN) H5N6 20160610.4275291
Avian influenza, human (45): WHO, human-animal interface 20160523.4239090
Avian influenza, human (44): China, H7N9, WHO 20160518.4228384
Avian influenza, human (43): China, H5N6, mutations, WHO 20160507.4205906
Avian influenza, human (34): China, H5N6, H7N9, WHO 20160325.4118113
2015
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Avian influenza, human (133): WHO assessment human-animal interface 20151220.3881202
Avian influenza, human (115): human-animal interface, SA status comments 20150718.3520025
Avian influenza, human (107): WHO assessment 20150521.3376485
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